Each allow advantages depending on the application. If you want "production" numbers... and are smart in how the molds are made... resin / epoxy could do great numbers.
BUT.... as SEALSKINNER stated... RTV could provide higher levels of detail... and intricacies. Remember.... its flexible .. and can stretch a little while your removing the molded item.
Advantages either way. You need to decide... for fun.... or money. Either way....Good Luck.